Negative regulation of dephosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPAT3, PLEC, and MILR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dephosphorylation activity versus GPAT3 in SOFT_TISSUE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPAT3 →	+3.733	+1.922	<.001	.003	3	6
SOFT_TISSUE	PLEC →	+1.336	+1.881	.001	.003	3	4
SOFT_TISSUE	MILR1 →	+3.356	+1.999	<.001	.002	3	4
SOFT_TISSUE	SPOCD1 →	+4.620	+1.714	<.001	<.001	3	4
PANCREAS	ALDH5A1 →	-1.040	-1.284	<.001	<.001	3	4
PANCREAS	SLC39A8 →	+1.518	+1.278	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035305 vs GPAT3 — SOFT_TISSUE

Explore this scatter interactively →