Regulation of dephosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL4, DOCK10, and FAM83H, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dephosphorylation activity versus RECQL4 in LUAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RECQL4 →	-0.732	-0.167	.002	<.001	3	6
LUAD	DOCK10 →	+0.695	+0.157	<.001	<.001	3	6
CCRCC	FAM83H →	-0.663	-0.207	.001	<.001	3	6
BRCA	TECR →	-0.599	-0.145	<.001	<.001	3	5
LUAD	ARHGEF6 →	+0.748	+0.179	<.001	<.001	3	5
OV	GPR65 →	+0.745	+0.130	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035303 vs RECQL4 — LUAD

Explore this scatter interactively →