Regulation of dephosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT5C, GPSM1, and LSM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dephosphorylation activity versus KMT5C in LUNG_NSCLC_LUSC (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KMT5C →	-0.890	-1.731	.002	<.001	3	5
OVARY	GPSM1 →	-1.368	-1.251	.001	.003	3	5
BONE	LSM4 →	-0.783	-1.332	<.001	.003	3	5
LUNG_SCLC	TCF12 →	-1.138	-0.882	<.001	.003	3	5
BONE	RUVBL1 →	-0.969	-1.348	<.001	.002	2	6
OVARY	MAST1 →	-1.029	-1.015	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035303 vs KMT5C — LUNG_NSCLC_LUSC

Explore this scatter interactively →