miRNA-mediated gene silencing by mRNA destabilization

Across TCGA patient cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAQP4, CYCSP6, and LINC01133, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by mRNA destabilization activity versus YWHAQP4 in GBM (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YWHAQP4 →	-1.441	-0.845	<.001	<.001	3	3
GBM	CYCSP6 →	-0.354	-0.577	.008	.007	3	3
LSCC	LINC01133 →	-0.946	-0.517	.003	.008	3	3
LSCC	DUSP16 →	-0.304	-0.696	.003	.003	3	3
HNSC	MIR181A1 →	-0.604	-0.658	.003	.001	3	3
CCRCC	LINC01792 →	-0.100	-0.872	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035279 vs YWHAQP4 — GBM

Explore this scatter interactively →