miRNA-mediated gene silencing by mRNA destabilization

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFDP2, PRDX4, and GET4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFDP2 grouped by miRNA-mediated gene silencing by mRNA destabilization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TFDP2 →	+0.681	+0.998	.001	.004	3	4
KIDNEY	PRDX4 →	-0.880	-1.272	<.001	.005	3	4
BLOOD_Leukemia	GET4 →	+0.673	+1.307	.002	<.001	3	4
STOMACH	COMMD2 →	+0.926	+1.877	.005	<.001	3	3
SKIN	SIAH2 →	+0.487	+1.073	.006	.004	3	3
OVARY	RWDD1 →	-0.706	-1.077	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFDP2 by miRNA-mediated gene silencing by mRNA destabilization activity — SKIN

Explore this box plot interactively →