miRNA-mediated gene silencing by mRNA destabilization

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR0B1, APOL4, and NPHP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR0B1 grouped by miRNA-mediated gene silencing by mRNA destabilization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NR0B1 →	-0.155	-0.094	.003	.001	3	5
LARGE_INTESTINE	APOL4 →	-0.256	-0.102	.007	.007	3	4
LARGE_INTESTINE	NPHP4 →	-0.224	-0.129	.003	.007	3	4
LUNG_SCLC	DHX38 →	+0.532	+0.154	.004	.001	2	5
SKIN	ACE →	-0.191	-0.102	<.001	<.001	3	4
SKIN	TAS2R31 →	+0.145	+0.062	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR0B1 by miRNA-mediated gene silencing by mRNA destabilization activity — PANCREAS

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