miRNA-mediated gene silencing by mRNA destabilization

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO2, MTBP, and AGO3, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by mRNA destabilization activity versus AGO2 in LUNG_NSCLC_LUSC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AGO2 →	+1.351	+0.156	<.001	<.001	3	18
BONE	MTBP →	+1.393	+0.141	.001	.005	3	17
STOMACH	AGO3 →	+1.649	+0.192	<.001	<.001	3	16
BONE	RBM12B →	+1.037	+0.136	<.001	.002	3	15
BLOOD_Lymphoma	DICER1 →	+0.943	+0.070	.007	.002	3	14
BLOOD_Lymphoma	SRSF3 →	+0.962	+0.066	.003	.009	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035279 vs AGO2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →