miRNA-mediated gene silencing by mRNA destabilization

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICE1, ISYNA1, and STMN3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by mRNA destabilization activity versus ICE1 in BREAST (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ICE1 →	+0.776	+0.250	.008	.008	3	3
CNS	ISYNA1 →	+3.319	+0.405	.003	.001	3	3
CNS	STMN3 →	+3.186	+0.405	.003	.001	3	3
CNS	C2orf74 →	-1.840	-0.584	.001	.009	3	3
LARGE_INTESTINE	ADAM22 →	+1.505	+0.459	.002	<.001	3	3
PANCREAS	CDK1 →	+1.266	+0.361	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035279 vs ICE1 — BREAST

Explore this scatter interactively →