Endocrine system development

Across TCGA cell cohorts, RNA activity of the Endocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT12, CDS1, and PRSS8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine system development activity versus GALNT12 in OESOPHAGUS (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GALNT12 →	+2.661	+0.289	.001	<.001	2	7
URINARY_TRACT	CDS1 →	+2.602	+1.629	.004	.001	3	6
URINARY_TRACT	PRSS8 →	+4.723	+1.112	<.001	.002	2	7
URINARY_TRACT	C1orf116 →	+2.603	+1.013	.001	.008	3	6
URINARY_TRACT	ANO9 →	+2.067	+1.009	<.001	.008	3	6
URINARY_TRACT	PERP →	+2.405	+1.002	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035270 vs GALNT12 — OESOPHAGUS

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