Protein O-linked mannosylation

Across TCGA cell cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABAT, USP6NL, and DIP2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked mannosylation activity versus ABAT in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ABAT →	+1.453	+1.428	.002	<.001	3	5
BLOOD_Leukemia	USP6NL →	-1.497	-1.169	.001	.005	3	4
BLOOD_Myeloma	DIP2C →	+2.932	+1.979	.005	<.001	3	4
CNS	SMPD1 →	+1.738	+1.301	.003	.006	3	4
BREAST	CDCA7 →	-1.747	-1.600	<.001	<.001	3	4
LARGE_INTESTINE	VAMP5 →	-1.119	-0.689	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035269 vs ABAT — SKIN

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