miRNA processing

Across TCGA patient cohorts, RNA activity of the miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRPEL1, DDAH2, and LAMA4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA processing activity versus GRPEL1 in OV (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRPEL1 →	-0.387	-0.040	.007	.001	3	7
BRCA	DDAH2 →	+0.423	+0.029	<.001	.001	3	7
UCEC	LAMA4 →	+0.462	+0.061	.004	.006	2	8
BRCA	EFEMP2 →	+0.691	+0.029	<.001	<.001	3	7
HNSC	NID2 →	+0.475	+0.091	<.001	.001	3	7
UCEC	FERMT2 →	+0.421	+0.051	.003	.003	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035196 vs GRPEL1 — OV

Explore this scatter interactively →