miRNA processing

Across TCGA patient cohorts, RNA activity of the miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPA, MTFR2, and SPAG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA processing activity versus CENPA in COAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPA →	+0.588	+0.221	<.001	<.001	3	5
LSCC	MTFR2 →	+0.579	+0.213	<.001	<.001	3	5
LSCC	SPAG5 →	+0.730	+0.200	.002	.001	3	5
BRCA	MEF2C →	-0.593	-0.187	<.001	<.001	3	5
BRCA	CNRIP1 →	-0.670	-0.263	.001	<.001	3	5
GBM	CLEC4GP1 →	-0.452	-0.260	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035196 vs CENPA — COAD

Explore this scatter interactively →