miRNA processing

Across TCGA cell cohorts, RNA activity of the miRNA processing pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53, HLA-C, and PRKRA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP53 grouped by miRNA processing-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TP53 →	-1.121	-0.328	<.001	.001	3	7
BLOOD_Leukemia	HLA-C →	+0.140	+0.209	.007	.008	3	6
CNS	PRKRA →	-0.277	-0.235	.004	.001	3	5
LUNG_NSCLC_LUSC	NUP155 →	-0.416	-0.255	.001	.001	3	5
SKIN	LGALS2 →	+0.150	+0.211	<.001	.001	3	4
SKIN	MAP1LC3A →	+0.372	+0.384	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP53 by miRNA processing activity — SKIN

Explore this box plot interactively →