miRNA processing

Across TCGA cell cohorts, RNA activity of the miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUFIP1, FBLN1, and PLAGL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUFIP1 grouped by miRNA processing-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NUFIP1 →	-0.546	-0.152	.008	.008	3	5
OVARY	FBLN1 →	-2.248	-0.139	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PLAGL2 →	-0.645	-0.115	.006	.006	3	4
BLOOD_Myeloma	VRK1 →	-0.837	-0.201	.007	<.001	3	4
BLOOD_Myeloma	ARHGEF39 →	-1.232	-0.159	.009	.008	2	5
URINARY_TRACT	REC8 →	+1.086	+0.203	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUFIP1 by miRNA processing activity — OVARY

Explore this box plot interactively →