miRNA processing

Across TCGA cell cohorts, RNA activity of the miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C15, BCAS4, and SNU13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA processing activity versus H4C15 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	H4C15 →	+1.952	+0.282	.001	.001	3	5
BLOOD_Lymphoma	BCAS4 →	-2.842	-0.227	.002	.004	3	5
OVARY	SNU13 →	-1.016	-0.250	<.001	.002	3	5
LIVER	EIF4H →	-0.464	-0.194	.005	.001	3	5
LARGE_INTESTINE	EFNA1 →	+1.102	+0.185	.006	.001	2	6
OVARY	MPZL3 →	+1.746	+0.226	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035196 vs H4C15 — BONE

Explore this scatter interactively →