Embryonic hemopoiesis

Across TCGA patient cohorts, RNA activity of the Embryonic hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK3, ZNF696, and POLG2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic hemopoiesis activity versus STK3 in LUAD (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STK3 →	+0.654	+0.366	<.001	.001	3	3
LUAD	ZNF696 →	+0.402	+0.268	.004	.003	3	3
UCEC	POLG2 →	+0.466	+0.700	.002	.002	3	3
LSCC	HMGN2 →	+0.342	+0.535	.009	<.001	3	3
LSCC	MMP28 →	-0.936	-0.463	.003	.007	3	3
GBM	CSTF1 →	+0.289	+0.349	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035162 vs STK3 — LUAD

Explore this scatter interactively →