Embryonic hemopoiesis

Across TCGA pan-cancer cohorts, RNA activity of the Embryonic hemopoiesis pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Embryonic hemopoiesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and THCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, KICH, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.768	0.909	<.001	147	view →
KICH	OS	Tertile	II,III,IV	0.322	0.958	<.001	75	view →
UVM	DFS	Quartile	All	0.139	1.000	<.001	65	view →
MESO	OS	Median	III,IV	0.420	0.683	<.001	64	view →
HNSC	DFS	Tertile	IV	0.716	0.535	.005	55	view →
LIHC	OS	Median	All	0.699	0.839	.003	32	view →
THCA	DFS	Median	All	0.906	0.776	.001	31	view →
LUSC	DFS	Quartile	III,IV	0.180	0.935	.003	27	view →
OV	OS	Quartile	III,IV	0.773	0.893	.012	24	view →
ACC	OS	Median	II,III,IV	0.756	0.934	.009	21	view →
UCEC	DFS	Median	All	0.601	0.676	.021	20	view →
COAD	OS	Quartile	All	0.817	0.914	.003	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0035162–KIRP (DFS)

Open the KIRP breakdown →