Embryonic hemopoiesis

Across TCGA cell cohorts, RNA activity of the Embryonic hemopoiesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANX3, TPM3, and OR4D11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PANX3 grouped by Embryonic hemopoiesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PANX3 →	+0.195	+1.138	.001	.005	3	3
OVARY	TPM3 →	-0.281	-1.497	.003	<.001	3	3
PANCREAS	OR4D11 →	-0.352	-1.925	.004	<.001	3	3
BREAST	TPBG →	-0.095	-0.601	.002	.009	3	2
BREAST	WASHC2C →	-0.110	-0.609	.004	.009	3	2
BREAST	GPR139 →	+0.126	+0.525	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PANX3 by Embryonic hemopoiesis activity — LUNG_SCLC

Explore this box plot interactively →