Embryonic hemopoiesis

Across TCGA cell cohorts, RNA activity of the Embryonic hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF168, RPL34, and RPL27A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic hemopoiesis activity versus RNF168 in STOMACH (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF168 →	-0.643	-1.142	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	RPL34 →	+0.951	+1.006	.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	RPL27A →	+1.095	+1.060	.003	.002	3	3
LARGE_INTESTINE	KRT23 →	+2.958	+0.442	.002	.009	3	3
LUNG_SCLC	UBXN7 →	-0.545	-0.858	.004	.001	3	3
URINARY_TRACT	PSMG1 →	-0.799	-1.042	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035162 vs RNF168 — STOMACH

Explore this scatter interactively →