Regulation of tube size

Across TCGA patient cohorts, RNA activity of the Regulation of tube size pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are U2SURP, COL15A1, and GNL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tube size activity versus U2SURP in LSCC (Pearson r = -0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	U2SURP →	-0.267	-0.047	<.001	<.001	3	9
GBM	COL15A1 →	+0.649	+0.052	<.001	<.001	3	9
LSCC	GNL3 →	-0.412	-0.047	<.001	<.001	3	9
GBM	PNN →	-0.328	-0.045	<.001	<.001	3	9
COAD	RFC1_S108 →	-0.507	-0.018	.001	.001	3	8
LSCC	RFC4 →	-0.567	-0.052	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035150 vs U2SURP — LSCC

Explore this scatter interactively →