Hindlimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Hindlimb morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, PRKG1, and SEPTIN7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindlimb morphogenesis activity versus MAP1A in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP1A →	+0.625	+0.060	<.001	<.001	3	9
OV	PRKG1 →	+0.744	+0.042	<.001	<.001	3	9
BRCA	SEPTIN7 →	+0.279	+0.046	<.001	<.001	3	8
OV	ILK →	+0.414	+0.051	<.001	<.001	3	8
OV	MSRB3 →	+0.648	+0.036	<.001	.004	3	8
OV	OLFML3 →	+0.991	+0.032	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035137 vs MAP1A — BRCA

Explore this scatter interactively →