Hindlimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Hindlimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRX, TBX3, and AIM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindlimb morphogenesis activity versus GLRX in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLRX →	-0.396	-0.373	.002	.001	3	5
BRCA	TBX3 →	+1.298	+0.465	<.001	<.001	3	5
UCEC	AIM2 →	-0.711	-0.198	.002	.004	3	4
HNSC	TNNT1 →	-1.945	-0.478	.001	<.001	3	4
LSCC	GSTM3 →	+0.915	+0.275	.007	.009	3	4
LSCC	FUT10 →	+0.395	+0.335	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035137 vs GLRX — LSCC

Explore this scatter interactively →