Hindlimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Hindlimb morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED1, ATP8B3, and COQ3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED1 grouped by Hindlimb morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MED1 →	-0.422	-1.414	.006	.002	3	10
BLOOD_Lymphoma	ATP8B3 →	+0.357	+1.971	.002	<.001	2	5
BLOOD_Lymphoma	COQ3 →	+0.334	+2.090	.002	.005	3	4
OVARY	TGS1 →	+0.208	+1.009	.005	.004	3	4
STOMACH	CTNNB1 →	-1.355	-1.121	<.001	.002	3	4
LUNG_SCLC	BCKDK →	-0.266	-1.375	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED1 by Hindlimb morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →