Hindlimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Hindlimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSPP1, ZKSCAN1, and PLPP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSPP1 grouped by Hindlimb morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CSPP1 →	-1.068	-1.645	.003	.002	3	5
LUNG_NSCLC_LUSC	ZKSCAN1 →	-1.106	-1.133	.001	.003	3	4
BONE	PLPP6 →	-1.607	-0.978	.002	.003	3	4
SKIN	RB1CC1 →	-0.628	-0.725	.004	.009	3	4
KIDNEY	EVA1A →	+1.660	+1.097	.002	.004	3	4
LARGE_INTESTINE	H3-3A →	-0.478	-0.894	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSPP1 by Hindlimb morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →