Forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EREG, ASPRV1, and CTNNB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EREG grouped by Forelimb morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EREG →	-0.393	-1.803	.001	<.001	3	4
BLOOD_Myeloma	ASPRV1 →	-0.788	-1.861	<.001	.001	3	4
STOMACH	CTNNB1 →	-1.303	-1.636	.001	.001	3	4
BLOOD_Myeloma	NIFK →	-0.410	-2.024	<.001	<.001	3	3
LUNG_NSCLC_LUAD	PA2G4P4 →	-0.178	-0.544	.002	.005	3	3
BLOOD_Myeloma	CCNI →	-0.371	-1.750	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EREG by Forelimb morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →