Embryonic hindlimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic hindlimb morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EML1, FSCN1_S39, and SEPTIN11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic hindlimb morphogenesis activity versus EML1 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EML1 →	+0.565	+0.076	<.001	.005	3	8
OV	FSCN1_S39 →	+0.753	+0.042	.002	.004	3	8
OV	SEPTIN11 →	+0.371	+0.060	<.001	<.001	3	7
BRCA	SEPTIN7 →	+0.276	+0.049	<.001	<.001	3	7
PDAC	B3GLCT →	+0.268	+0.037	.004	.002	2	8
BRCA	TLN2 →	+0.552	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035116 vs EML1 — UCEC

Explore this scatter interactively →