Embryonic hindlimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic hindlimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFS, KCTD3, and SPIDR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic hindlimb morphogenesis activity versus EFS in OV (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFS →	+1.042	+0.211	<.001	.004	2	5
HNSC	KCTD3 →	+0.660	+0.348	.002	.003	3	4
OV	SPIDR →	+0.579	+0.312	<.001	<.001	3	4
HNSC	TNFSF14 →	-0.505	-0.273	.004	.003	3	4
LSCC	GSTM3 →	+1.370	+0.498	.004	.007	3	4
HNSC	MYPN →	-1.260	-0.354	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035116 vs EFS — OV

Explore this scatter interactively →