Embryonic forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic forelimb morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU1F1, PDGFB, and STEAP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POU1F1 grouped by Embryonic forelimb morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POU1F1 →	+0.190	+1.530	<.001	.001	3	2
CNS	PDGFB →	+0.260	+1.458	.001	<.001	2	3
BREAST	STEAP4 →	-0.250	-0.989	<.001	<.001	3	2
BREAST	PLAAT2 →	+0.250	+0.808	<.001	.006	3	2
BREAST	MAGOH →	-0.504	-0.851	.001	.006	3	2
BREAST	ALDH1A1 →	-0.125	-0.830	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POU1F1 by Embryonic forelimb morphogenesis activity — CNS

Explore this box plot interactively →