Embryonic appendage morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic appendage morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL3, SEPTIN11, and TLN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic appendage morphogenesis activity versus FMNL3 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FMNL3 →	+0.346	+0.058	.001	<.001	3	9
HNSC	SEPTIN11 →	+0.369	+0.061	<.001	<.001	3	8
BRCA	TLN2 →	+0.531	+0.024	<.001	<.001	3	8
BRCA	EFEMP2 →	+0.521	+0.020	<.001	<.001	3	8
HNSC	PSME1 →	-0.446	-0.054	<.001	<.001	3	8
HNSC	PSME2 →	-0.563	-0.061	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035113 vs FMNL3 — UCEC

Explore this scatter interactively →