Embryonic appendage morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic appendage morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LETM2, ZNF490, and ARG2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LETM2 grouped by Embryonic appendage morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LETM2 →	-1.389	-0.484	<.001	.003	3	3
LARGE_INTESTINE	ZNF490 →	+0.527	+0.658	<.001	.008	3	3
LARGE_INTESTINE	ARG2 →	+1.472	+0.624	<.001	.008	3	3
LUNG_NSCLC_LUSC	LEPROTL1 →	+1.056	+0.369	.005	.004	3	3
LUNG_NSCLC_LUSC	EEF1G →	+0.726	+0.474	.001	.007	3	3
BLOOD_Lymphoma	RPL31 →	+0.658	+0.398	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LETM2 by Embryonic appendage morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →