Genitalia morphogenesis

Across TCGA cell cohorts, RNA activity of the Genitalia morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP23, CNNM1, and RAB3D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP23 grouped by Genitalia morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATP23 →	+0.672	+1.199	.008	.001	3	4
SOFT_TISSUE	CNNM1 →	+0.591	+1.150	<.001	.004	3	4
CNS	RAB3D →	+1.058	+0.972	<.001	.003	3	4
BLOOD_Lymphoma	PCOLCE →	+1.680	+2.226	.003	<.001	3	4
KIDNEY	FBXL16 →	+2.388	+1.454	.003	<.001	3	4
OESOPHAGUS	NDRG4 →	+1.251	+1.230	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP23 by Genitalia morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →