Appendage morphogenesis

Across TCGA patient cohorts, RNA activity of the Appendage morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP1, MFAP2, and CLEC11A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Appendage morphogenesis activity versus EFEMP1 in COAD (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EFEMP1 →	+0.528	+0.016	.001	.009	3	9
COAD	MFAP2 →	+0.534	+0.018	.001	.002	3	9
LSCC	CLEC11A →	+0.576	+0.044	<.001	<.001	3	9
LSCC	CNPY4 →	+0.401	+0.034	<.001	<.001	3	9
BRCA	OLFML3 →	+0.958	+0.033	<.001	<.001	3	9
BRCA	PARVA →	+0.523	+0.027	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035107 vs EFEMP1 — COAD

Explore this scatter interactively →