Appendage morphogenesis

Across TCGA cell cohorts, RNA activity of the Appendage morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRID1, ANXA1, and INSL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRID1 grouped by Appendage morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GRID1 →	-0.256	-1.770	.008	.002	3	4
LUNG_NSCLC_LUSC	ANXA1 →	+0.223	+0.349	.001	.001	3	4
SKIN	INSL6 →	-0.260	-1.240	<.001	<.001	3	3
SKIN	GIMAP6 →	-0.244	-1.593	.004	.002	3	3
BLOOD_Lymphoma	C1QTNF2 →	-0.417	-1.254	.002	.004	3	3
BLOOD_Lymphoma	TOMM7 →	+0.333	+1.496	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRID1 by Appendage morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →