Appendage morphogenesis

Across TCGA cell cohorts, RNA activity of the Appendage morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PET117, THADA, and NDRG4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Appendage morphogenesis activity versus PET117 in SKIN (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PET117 →	-0.455	-0.919	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	THADA →	-0.970	-0.608	.001	.008	3	3
LUNG_NSCLC_LUAD	NDRG4 →	+1.472	+0.795	<.001	.004	3	3
LUNG_NSCLC_LUAD	MEST →	+1.532	+0.723	.004	.001	3	3
LUNG_NSCLC_LUAD	RAPGEF5 →	+1.327	+0.808	.002	.002	3	3
BLOOD_Leukemia	USP2 →	-1.009	-1.010	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035107 vs PET117 — SKIN

Explore this scatter interactively →