Response to nicotine

Across TCGA cell cohorts, RNA activity of the Response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USO1, APIP, and PWWP3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USO1 grouped by Response to nicotine-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	USO1 →	-1.023	-1.240	.003	.003	3	4
OESOPHAGUS	APIP →	+1.081	+0.333	.007	.009	3	3
BLOOD_Leukemia	PWWP3A →	+1.158	+0.714	<.001	.006	3	3
BLOOD_Leukemia	CBX6 →	+0.793	+0.696	<.001	.006	3	3
LIVER	PRPF39 →	-0.493	-1.059	.008	.004	3	3
URINARY_TRACT	ZNF471 →	-0.645	-0.211	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USO1 by Response to nicotine activity — SOFT_TISSUE

Explore this box plot interactively →