Sperm DNA condensation

Across TCGA patient cohorts, RNA activity of the Sperm DNA condensation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPK1, UBE2NL, and STIL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm DNA condensation activity versus SRPK1 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPK1 →	+0.523	+0.742	<.001	<.001	3	6
OV	UBE2NL →	-0.798	-0.433	.004	<.001	3	4
LSCC	STIL →	+0.514	+0.553	.004	.002	2	5
LSCC	DNA2 →	+0.536	+0.394	.004	.008	3	4
PDAC	BUB1 →	+0.537	+0.267	.002	<.001	3	4
PDAC	CDK1 →	+0.669	+0.305	.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035092 vs SRPK1 — BRCA

Explore this scatter interactively →