Sperm DNA condensation

Across TCGA pan-cancer cohorts, RNA activity of the Sperm DNA condensation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Sperm DNA condensation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CHOL and UCS, show the opposite pattern, with higher activity associated with better survival.

ACC, BRCA, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.277	0.736	<.001	70	view →
BRCA	DFS	Tertile	III,IV	0.809	0.935	.002	38	view →
CHOL	OS	Tertile	All	0.892	0.145	.002	31	view →
UCS	OS	Tertile	IV	1.000	0.156	.024	30	view →
UVM	OS	Quartile	All	1.000	0.535	.016	27	view →
LAML	DFS	Median	All	0.685	0.489	.006	24	view →
SKCM	OS	Median	III,IV	0.857	0.762	.007	22	view →
LUSC	DFS	Quartile	All	0.857	0.710	.001	19	view →
THCA	DFS	Median	III,IV	0.596	0.886	.001	19	view →
GBM	DFS	Median	All	0.325	0.197	.002	18	view →
COAD	OS	Median	II,III,IV	0.405	0.785	.007	16	view →
THYM	OS	Median	All	0.952	0.798	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0035092–ACC (DFS)

Open the ACC breakdown →