Sperm DNA condensation

Across TCGA cell cohorts, RNA activity of the Sperm DNA condensation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQLE, STOM, and ZDHHC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm DNA condensation activity versus SQLE in PANCREAS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SQLE →	-1.805	-1.238	.002	.005	3	3
PANCREAS	STOM →	-2.065	-1.316	.006	.003	3	3
PANCREAS	ZDHHC18 →	-0.539	-1.220	.006	<.001	3	3
LARGE_INTESTINE	MMACHC →	+0.751	+0.943	<.001	<.001	3	3
BLOOD_Myeloma	INPPL1 →	-1.445	-1.403	.006	.002	2	4
BONE	GNAL →	+1.800	+1.612	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035092 vs SQLE — PANCREAS

Explore this scatter interactively →