Cardiocyte differentiation

Across TCGA patient cohorts, RNA activity of the Cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA4, HSPG2, and PEAK1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiocyte differentiation activity versus LAMA4 in THYM (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	LAMA4 →	+1.509	+0.031	<.001	<.001	3	30
THYM	HSPG2 →	+1.848	+0.034	<.001	<.001	3	30
THYM	PEAK1 →	+1.385	+0.039	<.001	<.001	3	30
DLBC	CDH5 →	+1.385	+0.034	<.001	.001	3	30
THYM	PCDH18 →	+2.577	+0.040	<.001	<.001	3	30
SARC	ABCC9 →	+1.604	+0.036	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035051 vs LAMA4 — THYM

Explore this scatter interactively →