Cardiocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Cardiocyte differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 160 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Cardiocyte differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and UCS, show the opposite pattern, with higher activity associated with better survival.

COAD, THCA, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	IV	0.138	0.627	<.001	49	view →
THCA	OS	Tertile	II,III,IV	0.709	0.956	<.001	49	view →
OV	DFS	Quartile	III,IV	0.310	0.422	.020	44	view →
ACC	DFS	Tertile	All	0.210	0.738	.001	26	view →
UVM	OS	Median	II,III,IV	0.806	0.400	.007	20	view →
TGCT	DFS	Quartile	All	0.532	0.790	.015	18	view →
UCS	DFS	Median	III,IV	0.571	0.274	.014	16	view →
CESC	DFS	Median	All	0.742	0.863	.002	14	view →
LIHC	DFS	Quartile	All	0.464	0.618	.012	13	view →
ESCA	OS	Median	IV	0.135	0.568	.031	12	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.819	.017	10	view →
HNSC	DFS	Median	III,IV	0.675	0.536	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035051–COAD (DFS)

Open the COAD breakdown →