Cardiocyte differentiation

Across TCGA patient cohorts, RNA activity of the Cardiocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN2, SYNPO, and CAVIN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiocyte differentiation activity versus SEPTIN2 in UCEC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN2 →	+0.362	+0.069	<.001	<.001	3	10
UCEC	SYNPO →	+0.640	+0.059	<.001	<.001	3	10
UCEC	CAVIN2 →	+0.976	+0.062	<.001	<.001	3	10
BRCA	COL1A1 →	+0.835	+0.044	<.001	<.001	3	10
CCRCC	PALLD →	+0.841	+0.040	<.001	<.001	3	10
UCEC	TNS2_S120 →	+0.685	+0.061	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035051 vs SEPTIN2 — UCEC

Explore this scatter interactively →