Cardiocyte differentiation

Across TCGA patient cohorts, RNA activity of the Cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRCH2, ADAD2, and LRFN5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiocyte differentiation activity versus LRCH2 in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LRCH2 →	+0.666	+1.125	.004	.007	3	2
COAD	ADAD2 →	+0.042	+1.484	.009	.001	3	2
COAD	LRFN5 →	+0.280	+1.314	.001	.002	3	2
BRCA	MRPS7 →	-0.953	-0.193	.003	.004	3	2
BRCA	VEGFD →	+1.186	+0.205	.007	.004	3	2
BRCA	MRPL12 →	-1.137	-0.245	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035051 vs LRCH2 — COAD

Explore this scatter interactively →