Cardiocyte differentiation

Across TCGA cell cohorts, RNA activity of the Cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC3, RNF38, and ADM, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHDC3 grouped by Cardiocyte differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLHDC3 →	-0.776	-0.290	.003	<.001	3	3
LUNG_SCLC	RNF38 →	-1.113	-0.236	<.001	.002	3	3
LUNG_SCLC	ADM →	+2.217	+0.220	.003	.001	3	3
LUNG_SCLC	PDE7A →	-1.395	-0.240	.001	.006	3	3
OESOPHAGUS	ANGPTL3 →	+0.166	+0.296	.005	.003	3	3
OESOPHAGUS	LRRC37A2 →	+1.830	+0.329	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHDC3 by Cardiocyte differentiation activity — LUNG_SCLC

Explore this box plot interactively →