Cardiocyte differentiation

Across TCGA cell cohorts, RNA activity of the Cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR39, TSPAN4, and TAGLN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiocyte differentiation activity versus GPR39 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPR39 →	+1.924	+0.232	.006	.009	3	6
OESOPHAGUS	TSPAN4 →	+1.074	+0.238	.001	.004	3	6
SOFT_TISSUE	TAGLN2 →	+4.306	+0.291	.007	.003	3	6
SOFT_TISSUE	SMAD3 →	+1.950	+0.271	.008	.007	3	6
OESOPHAGUS	ACTN4 →	+1.492	+0.270	<.001	.001	3	5
SOFT_TISSUE	ASPH →	+2.123	+0.204	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035051 vs GPR39 — STOMACH

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