Positive regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPT1, DOCK8, and SERBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPT1 grouped by Positive regulation of Rho protein signal transduction-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPT1 →	-0.843	-0.997	.003	.005	3	5
BREAST	DOCK8 →	+1.570	+0.601	<.001	.004	3	3
SKIN	SERBP1 →	-0.514	-0.296	.001	.002	2	4
SKIN	PEX3 →	-0.504	-0.663	.001	.005	3	3
KIDNEY	CCDC163 →	-1.261	-1.046	<.001	.007	3	3
LARGE_INTESTINE	GNB3 →	-0.908	-0.360	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPT1 by Positive regulation of Rho protein signal transduction activity — PANCREAS

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