Negative regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of Rho protein signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD70, COPS5, and ZNF660, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD70 grouped by Negative regulation of Rho protein signal transduction-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD70 →	+0.146	+0.245	.009	.004	3	4
SKIN	COPS5 →	-0.372	-0.590	<.001	.004	3	3
LARGE_INTESTINE	ZNF660 →	+0.162	+0.969	.001	.007	3	3
URINARY_TRACT	MAGOHB →	+0.096	+0.525	.004	<.001	3	3
OVARY	GLUD1 →	+0.183	+0.236	.004	.009	3	3
LUNG_NSCLC_LUSC	HOXB4 →	+0.253	+0.182	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD70 by Negative regulation of Rho protein signal transduction activity — OESOPHAGUS

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