Regulation of Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBCK, GRM3, and ANO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rac protein signal transduction activity versus TBCK in LUAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBCK →	+0.226	+0.464	.006	.007	2	5
GBM	GRM3 →	+0.997	+0.180	<.001	.006	3	4
GBM	ANO3 →	+0.568	+0.341	.002	<.001	3	4
LUAD	SMIM8 →	+0.350	+0.547	<.001	.002	3	3
LUAD	SWT1 →	+0.278	+0.730	.003	<.001	3	3
LUAD	THAP1 →	+0.303	+0.448	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035020 vs TBCK — LUAD

Explore this scatter interactively →