Somatic stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Somatic stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA4, VCAN, and MYLK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic stem cell population maintenance activity versus SERPINA4 in BRCA (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINA4 →	+0.580	+0.040	<.001	<.001	3	6
BRCA	VCAN →	+0.617	+0.026	.002	.001	3	6
GBM	MYLK →	+0.440	+0.037	.008	.005	3	6
HNSC	LAMC1 →	+0.475	+0.064	<.001	<.001	3	6
HNSC	NID1 →	+0.469	+0.057	<.001	<.001	3	6
CCRCC	LMOD1_S85 →	+0.851	+0.036	.006	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035019 vs SERPINA4 — BRCA

Explore this scatter interactively →