Mitochondrial protein processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial protein processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRN3_S229, PBXIP1_S469, and RUNX1_T14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial protein processing activity versus STRN3_S229 in LSCC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STRN3_S229 →	-0.340	-0.045	.001	.005	3	5
LSCC	PBXIP1_S469 →	-0.915	-0.046	.004	.005	3	5
LSCC	RUNX1_T14 →	-0.562	-0.053	<.001	<.001	3	4
LSCC	SART3 →	+0.245	+0.049	<.001	.001	3	4
HNSC	SNRNP48 →	+0.331	+0.053	.003	.004	3	4
HNSC	WRNIP1 →	+0.313	+0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034982 vs STRN3_S229 — LSCC

Explore this scatter interactively →