Mitochondrial protein processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial protein processing pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HCC1L, RSRC1, and CEP290, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial protein processing activity versus R3HCC1L in OV (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	R3HCC1L →	-0.498	-0.128	.001	.002	3	6
LSCC	RSRC1 →	-0.503	-0.275	<.001	<.001	3	6
LSCC	CEP290 →	-0.400	-0.278	<.001	<.001	3	6
LSCC	VRK1 →	-0.686	-0.346	.001	<.001	3	5
PDAC	ANKRD36 →	-0.298	-0.228	.002	<.001	3	5
LSCC	TPRKB →	-0.607	-0.305	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034982 vs R3HCC1L — OV

Explore this scatter interactively →